Misidentified anatomy
The most consequential intraoperative error in cholecystectomy is misidentifying the common bile duct as the cystic duct. The two structures sit in close proximity, and in an inflamed or obscured field they can look nearly identical from a laparoscopic camera angle. When the surgeon clips and cuts what they believe is the cystic duct — and it is actually the common bile duct — the injury is often a Strasberg E-class transection that requires major reconstruction.
This is the error the critical view of safety was designed to prevent. The technique, published by Strasberg and Brunt in 1995 and adopted as standard by every major surgical society, requires three conditions before any clip or cut: the triangle of Calot is cleared, the lower third of the gallbladder is visible, and only two structures — the cystic duct and cystic artery — enter the gallbladder.


